Nitrofurazone + Urea Veterinary Bolus is an antimicrobial and anti-inflammatory formulation indicated primarily for the treatment of bacterial infections in livestock. Nitrofurazone is a nitrofuran-class broad-spectrum antibacterial, while Urea acts as a protein-denaturant with mild anti-inflammatory and osmotic diuretic properties.

This combination is especially useful in metritis, pyometra, wound infections, and systemic bacterial diseases in large animals.

Composition per bolus:

•  Nitrofurazone I.P. – 60 mg

•  Urea – 6 mg

•  Excipients – q.s.

Excipients may include: Lactose, maize starch, PVP, magnesium stearate, and other permitted binders and disintegrants suitable for veterinary use.

Dosage Form: Solid Oral Veterinary Bolus

Appearance: Small oblong bolus, typically light yellow or tan; uncoated or coated; packed in blister or strip form.

Pharmacological Class:

•  Nitrofurazone: Nitrofuran Antimicrobial

•  Urea: Protein denaturant, osmotic adjunct

Therapeutic Class:

•  Antibacterial

•  Anti-inflammatory (supportive)

•  Intrauterine antimicrobial (if prescribed via alternate route)

Recommended for the treatment and supportive care of:

•  Uterine infections: Metritis, Pyometra, Endometritis

•  Post-parturition bacterial contamination

•  Systemic bacterial infections (enteric or respiratory)

•  Septic wounds and abscesses (oral use, not topical)

•  Adjuvant therapy with systemic antibiotics

•  Dosage Form: Veterinary Oral Bolus

•  Available Pack Sizes:

            o  10 × 5 (50 boluses per carton; 5 boluses per strip)

           o  2 × 6 (12 boluses per carton; 6 boluses per strip)

•  Outer Carton: Printed laminated box with usage and storage info

•  Target Species: Cattle, Buffalo, Sheep, Goats (as advised by veterinarian)

Route: Oral (standard use); also prescribed intrauterine by some vets in reproductive disorders

Recommended Dosage (oral use):

•  Cattle/Buffalo: 2–4 boluses once or twice daily for 2–3 days

•  Small ruminants: 1–2 boluses daily depending on weight

Veterinarian may adjust dose based on severity, route, and infection type

•  Effective against a wide range of gram-positive and gram-negative bacteria

•  Dual mechanism: bacteriostatic (Nitrofurazone) + osmotic effect (Urea)

•  Useful in uterine and systemic infections

•  Can be used with systemic antibiotics for enhanced efficacy

•  Easy to administer in bolus form for field application

Rare, but may include:

•  Mild gastrointestinal upset

•  Allergic or hypersensitivity reactions

•  Possible local irritation if used intrauterine (veterinary discretion required)

•  Potential impact on fertility with chronic or repeated use

•  Use under veterinary supervision only

•  Avoid use in pregnant animals unless deemed necessary

•  Do not crush or dissolve for feed or water administration

•  Ensure proper hydration during treatment

•  Not recommended for long-term or prophylactic use

•  Meat: Minimum 28 days

•  Milk: Minimum 7 days

Follow withdrawal instructions strictly to avoid residue in food chain.

•  Store below 30°C in a cool, dry, and dark place

•  Keep away from moisture, sunlight, and heat

•  Do not use if packaging is damaged or past expiry

•  Keep away from children and non-target species

•  Use disposable gloves during handling and administration

•  Avoid contact with eyes and skin

•  Do not chew, split, or crush the bolus

•  Wash hands thoroughly after use

•  Dispose of unused product in accordance with local regulations

•  Schedule H veterinary preparation (Prescription required)

•  Regulated under Drugs and Cosmetics Act (India) and local veterinary authorities

•  Not for sale or use without veterinary authorization

•  HS Code (International): 3004.90 – Medicaments for veterinary use

•  HSN Code (India): 30049099 – Other medicaments, not elsewhere classified (veterinary use)

Veterinary Use Only

•  Not for human consumption or administration

•  Formulated specifically for animal physiology

•  Human exposure may result in toxicity, hypersensitivity, or resistance concerns

•  May be used alongside antibiotic therapy, fluids, or supportive treatment

•  In intrauterine uses (by vet only), ensure proper sanitation and technique

•  Do not use repeatedly without medical need

•  Conduct veterinary reassessment if no improvement is seen in 48–72 hours

Q: What is Nitrofurazone used for in veterinary medicine?

A: It is a broad-spectrum antibacterial used for uterine infections, wounds, and other bacterial diseases.

Q: Why is Urea included in this bolus?

A: Urea supports antibacterial action through protein denaturation and helps reduce inflammation and fluid accumulation.

Q: Can this be used in lactating animals?

A: Yes, but observe a 7-day milk withdrawal post-treatment.

Q: Is this bolus for oral or intrauterine use?

A: Primarily for oral use, but may be prescribed intrauterine only by veterinarians in certain reproductive infections.