Strepto Penicillin Injection is a sterile dry powder formulation containing a combination of Benzylpenicillin (Penicillin G) and Streptomycin Sulfate designed for veterinary use. This combination provides broad-spectrum antibacterial activity, effective against many Gram-positive and Gram-negative bacteria commonly implicated in veterinary infections.

Administered parenterally after reconstitution with sterile water, this preparation is ideal for systemic infections requiring prompt antimicrobial intervention in livestock and other animals.

•  Dosage Form: Sterile lyophilized powder for injection

•  Appearance (Dry Powder): White to pale yellow crystalline powder

•  Appearance (Reconstituted Solution): Clear, colourless to pale yellow solution

•  pH (Reconstituted Solution): Approximately 6.5 to 7.5

•  Sterility: Complies with veterinary pharmacopoeia standards

•  Assay: Meets labelled potency for both active ingredients

•  Container: Mono carton tray packaging including vial(s) and sterile water ampoule(s)

Each vial contains:

•  Benzylpenicillin Potassium or Sodium equivalent – amount to deliver 2.5 gm or 5 gm total penicillin activity

•  Streptomycin Sulphate – equivalent to corresponding streptomycin content per veterinary standards

•  Excipients: Pharmacopeial-grade stabilizers and bulking agents

•  Sterile Water for Injection: Supplied in mono carton tray for reconstitution

•  Therapeutic Class: Antibiotic combination

•  Mechanism of Action: Benzylpenicillin inhibits bacterial cell wall synthesis causing cell lysis; Streptomycin interferes with protein synthesis by binding to the 30S ribosomal subunit, exerting bactericidal effect especially on aerobic Gram-negative bacteria. The combination provides synergistic broad-spectrum antibacterial coverage.

Used to treat infections caused by susceptible bacteria, including:

•  Respiratory tract infections

•  Septicemia

•  Foot rot and wound infections

•  Mastitis

•  Enteritis

•  Other systemic and localized infections in cattle, sheep, goats, pigs, and other species

Route:

•  Intramuscular (I.M.) injection

Dosage:

•  10,000 to 20,000 IU penicillin/kg body weight once or twice daily, or as prescribed

•  Duration: 3–7 days depending on infection severity and clinical response

Preparation:

•  Reconstitute the dry powder with the supplied sterile water immediately before use.

•  Sterile dry powder for injection in vial(s)

•  Packaged in mono cartoon tray containing vial(s) and ampoule(s) of sterile water

•  Available vial sizes: 2.5 gm and 5 gm

•  Broad-spectrum antibacterial efficacy combining penicillin and streptomycin

•  Synergistic action enhancing treatment outcomes

•  Convenient mono carton packaging with sterile water for easy preparation

•  Suitable for treatment of a wide range of veterinary infections

•  Local irritation or pain at injection site

•  Hypersensitivity reactions (rare) including anaphylaxis

•  Possible ototoxicity and nephrotoxicity at high doses (streptomycin component)

•  Contraindicated in animals allergic to penicillin or aminoglycosides

•  Avoid in animals with renal impairment or hearing disorders

•  Administer cautiously in debilitated or dehydrated animals

•  Strictly follow veterinary guidance and withdrawal periods

•  Meat: Minimum 21 days

•  Milk: Minimum 3 days

Withdrawal times may vary with local regulations; always comply with applicable rules.

•  Store below 25°C in a dry, dark place

•  Protect from moisture and light

•  Use immediately after reconstitution

•  Dispose of unused product responsibly

•  Handle with care to avoid human exposure

•  Veterinary prescription-only medicine

•  Regulated under Schedule H or equivalent

•  Not for human use

•  HS Code (International): 3004.90 – Medicaments for veterinary use

•  HSN Code (India): 3004.90.99 – Veterinary antibiotic combinations

•  Use aseptic technique during reconstitution and administration

•  Complete full prescribed course to prevent resistance

•  Do not mix with other drugs unless compatibility is confirmed

•  Monitor for adverse reactions during treatment

Q1: What bacteria does Strepto Penicillin treat?

A: It targets a wide range of Gram-positive and Gram-negative bacteria, including those causing respiratory and systemic infections.

Q2: Can this be used in all food-producing animals?

A: Yes, but withdrawal periods must be strictly observed.

Q3: How should the injection be prepared?

A: Reconstitute the powder with the sterile water supplied immediately before injection.

Q4: Are there risks of allergic reactions?

A: Yes, hypersensitivity to penicillin or streptomycin is possible; monitor animals carefully.

Q5: Can the reconstituted solution be stored?

A: No, use immediately after preparation.