This injectable veterinary formulation combines Ceftiofur Sodium, a third-generation cephalosporin antibiotic, with Tazobactam Sodium, a potent β-lactamase inhibitor.

Ceftiofur acts by inhibiting bacterial cell wall synthesis, leading to bactericidal activity against a broad spectrum of pathogens. Tazobactam enhances efficacy by inhibiting β-lactamase enzymes produced by resistant bacteria, thus extending the antimicrobial spectrum.

This combination is used to treat serious bacterial infections in animals where β-lactamase producing pathogens are involved.

•  Dosage Form: Sterile lyophilized powder for injection

•  Appearance (Dry Powder): White to off-white crystalline powder

•  Appearance (Reconstituted Solution): Clear to slightly opalescent solution

•  pH (Reconstituted Solution): 5.5 – 7.0

•  Sterility: Complies with veterinary pharmacopeial standards

• Assay: 90% – 110% of labelled content for both active ingredients

•  Container: Type I glass vial with rubber stopper and aluminium seal

Each vial contains:

•  Ceftiofur Sodium U.S.P. – 1 gm

•  Tazobactam Sodium U.S.P. – 125 mg

•  Excipients: q.s.

•  Sterile Water for Injection: Supplied separately for reconstitution

•  Therapeutic Class: Antibiotic + β-lactamase inhibitor combination

•  Mechanism of Action: Ceftiofur inhibits bacterial cell wall synthesis, while Tazobactam blocks β-lactamase enzymes, protecting Ceftiofur from enzymatic degradation and broadening the antibacterial spectrum.

Indicated for the treatment of infections caused by β-lactamase producing and susceptible bacteria in:

•  Respiratory tract infections in cattle, swine, and other livestock

•  Mastitis and metritis in cattle

•  Urinary tract infections

•  Skin and soft tissue infections

•  Septicaemia and systemic infections

Route:

•  Intramuscular (I.M.) or Subcutaneous (S.C.) injection

Dosage:

•  Cattle: 1 mg/kg body weight once daily or as prescribed

•  Swine and other animals: Dose adjusted based on veterinary guidance

•  Duration: Typically 3–5 days depending on infection severity

Reconstitution:

•  Reconstitute with the sterile water supplied immediately prior to use

  •Use aseptic technique and administer promptly

•  Sterile dry powder for injection

•  Vial size: 1.125 gm (1 gm Ceftiofur + 125 mg Tazobactam)

•  Pack includes sterile water ampoule for reconstitution

•

Broad-spectrum cephalosporin with β-lactamase inhibitor protection

•  Effective against resistant bacteria producing β-lactamase enzymes

•  Rapid bactericidal action

•  Suitable for diverse veterinary infections

•  Convenient single-dose formulation

•  Local injection site reactions (swelling, pain)

•  Allergic reactions (rare)

•  Gastrointestinal upset in sensitive animals (rare)

•  Contraindicated in animals with known hypersensitivity to cephalosporins or β-lactam antibiotics

•  Use cautiously in animals with renal impairment

•  Avoid intravenous administration unless specifically directed

•  Strictly follow veterinary prescription

•  Observe withdrawal periods carefully

•  Meat: Minimum 7 days

•  Milk: Minimum 3 days

Withdrawal times may vary by jurisdiction and should comply with local regulatory requirements.

•  Store below 25°C in a dry, protected place

•  Protect from light and moisture

•  Do not freeze

•  Use immediately after reconstitution

•  Dispose of unused product responsibly

•  Prescription-only veterinary medicine

•  Regulated under Schedule H or local equivalents

•  Not intended for human use

•  HS Code (International): 3004.90 – Medicaments for veterinary use

•  HSN Code (India): 3004.90.99 – Veterinary antibiotic combinations

•  Use aseptic technique for preparation and injection

•  Complete full course to avoid resistance development

•  Do not mix with other drugs unless compatibility is confirmed

•  Monitor animals for any adverse reactions

Q1: What is the role of Tazobactam in this combination?

A: Tazobactam inhibits β-lactamase enzymes, protecting Ceftiofur from degradation and enhancing antibacterial spectrum.

Q2: Can this combination treat resistant bacterial infections?

A: Yes, it is effective against many β-lactamase producing resistant bacteria.

Q3: Is this safe for all animal species?

A: It is generally safe but must be used under veterinary supervision with species-specific dosing.

Q4: How soon after reconstitution should it be used?

A: Immediately, to maintain sterility and effectiveness.

Q5: What is the withdrawal period for milk?

A: Minimum 3 days, but always check local regulations.