Ceftizoxime for Injection is a sterile, lyophilized powder intended for parenteral use in animals. It contains Ceftizoxime, a third-generation cephalosporin antibiotic known for its broad-spectrum bactericidal activity, including against many Gram-positive and Gram-negative pathogens.

Ceftizoxime is highly stable against most β-lactamase enzymes, allowing it to remain effective in infections caused by resistant bacterial strains. It exhibits excellent tissue penetration, making it highly effective in deep-seated infections.

The formulation is supplied as a dry powder to be reconstituted with sterile water immediately before administration.

•  Dosage Form: Sterile lyophilized powder for injection

•  Appearance (Dry Powder): White to off-white crystalline powder

•  Appearance (After Reconstitution): Clear to slightly opalescent solution

•  pH (Reconstituted Solution): 5.0 to 7.0 (approx.)

•  Sterility: Must comply with pharmacopeial standards (USP)

•  Bacterial Endotoxins: Within USP permissible limits

•  Assay: 90% – 110% of labelled content

•  Moisture Content: Within allowable pharmacopeial range

•  Container Integrity: Type I glass vials, sealed with rubber stoppers and aluminium flip-off caps

Each vial contains:

•  Ceftizoxime (as Ceftizoxime Sodium U.S.P.) – 1.5 gm or 3.0 gm

•  Excipients – q.s.

•  Sterile Water for Injection – Provided in the pack (free) for reconstitution

•  Therapeutic Class: Antimicrobial Agent

•  Drug Class: Third-generation cephalosporin (β-lactam antibiotic)

•  Mechanism of Action: Ceftizoxime binds to penicillin-binding proteins (PBPs) on bacterial cell walls, inhibiting cell wall synthesis and resulting in cell lysis and death.

Ceftizoxime is indicated for the treatment of bacterial infections in animals caused by susceptible organisms, including:

•  Respiratory tract infections (e.g. pneumonia, bronchitis)

• Genito-urinary tract infections

•  Gastrointestinal tract infections

•  Septicaemia and bacteraemia

•  Mastitis, metritis, and other post-parturient infections

•  Skin, soft tissue, and wound infections

•  Bone and joint infections (in selected cases)

Species: Suitable for use in cattle, buffalo, sheep, goats, pigs, dogs, and cats.

Route:

•  Intramuscular (I.M.) or

•  Intravenous (I.V.) injection

Dosage Guidelines:

•  Large Animals (Cattle, Buffalo, etc.): 20–30 mg/kg body weight once or twice daily

•  Small Animals (Dogs, Cats, etc.): 25–50 mg/kg once or twice daily

•  Duration: 3–5 days, extendable based on clinical response

Note: Use immediately after reconstitution with provided sterile water.

•  Form: Sterile dry powder for injection

•  Available Pack Sizes:

    o  1.5 gm vial

    o  3.0 gm vial

•  Each pack includes:

     o  1 glass vial of sterile powder

     o  1 ampoule/vial of sterile water for injection (free)

•  High stability against β-lactamases

•  Broad-spectrum coverage

•  Excellent bioavailability and tissue penetration

•  Effective for deep and systemic infections

•  Well tolerated across major veterinary species

•  Ideal for single or twice-daily dosing

•  Mild local pain or swelling at injection site

•  Hypersensitivity reactions: rash, anaphylaxis (rare)

•  Gastrointestinal effects (more common in small animals): vomiting, diarrhoea

•  Altered kidney or liver parameters (rare, in long-term use)

•  Contraindicated in animals with known cephalosporin or penicillin allergy

•  Use cautiously in animals with severe renal impairment

•  Do not mix with other medications in the same syringe unless compatibility is confirmed

• Not recommended for use in neonates unless prescribed by a veterinarian

•  Meat: 28 days after last injection

•  Milk: 7 days after last injection

Ensure full withdrawal periods are followed before slaughter or milk collection

•  Store below 25°C in a dry place

•  Protect from light and moisture

•  Do not freeze

•  Use reconstituted solution immediately

•  Discard any unused portion responsibly

•  Maintain cold-chain during transport if required

•  Prescription Drug – Veterinary Only

•  Regulated under Schedule H1 or local equivalents

•  Not for human use

•  HS Code (International): 3004.20 – Medicaments containing antibiotics

•  HSN Code (India): 3004.20.90 – Other antibiotic formulations

•  Reconstitute only with the sterile water provided

•  Do not split vials or reuse remaining contents

•  Always complete the full course as prescribed

•  Avoid use in animals intended for breeding unless approved by a veterinarian

•  Follow all relevant veterinary drug regulations and good stewardship practices

Q1: What is Ceftizoxime?

A: Ceftizoxime is a third-generation cephalosporin antibiotic with broad-spectrum bactericidal activity used in veterinary infections.

Q2: Can it treat resistant bacterial infections?

A: Yes, it is effective against many β-lactamase producing strains due to its chemical stability.

Q3: Can it be used during pregnancy or lactation?

A: Use only under the direction of a veterinarian after assessing risk-benefit.

Q4: Is this safe for puppies or calves?

A: Use with caution in neonates or very young animals. Dosage adjustment may be necessary.

Q5: Can reconstituted solution be stored for later use?

A: No. It should be used immediately after mixing. Discard any unused solution.

Q6: Can it be given with other antibiotics?

A: Avoid mixing in the same syringe unless confirmed compatible. Consult a veterinarian.