This veterinary oral powder formulation contains a synergistic antimicrobial combination of Sulphadiazine I.P. 10% w/w and Trimethoprim I.P. 2% w/w, designed for broad-spectrum antibacterial activity in livestock and poultry. Sulphadiazine, a sulphonamide, inhibits folic acid synthesis at an early step, while Trimethoprim, a diaminopyrimidine, inhibits a later step in the same pathway. When used together, they provide a potentiated bactericidal effect through sequential blockade of microbial folate synthesis.

•  Appearance: Fine, off-white to pale yellow free-flowing powder

•  Identification: Conforms to I.P. specifications for both Sulphadiazine and Trimethoprim using UV spectrophotometry and HPLC

•  Assay:

      o  Sulphadiazine I.P.: 10% w/w

      o  Trimethoprim I.P.: 2% w/w

•  Loss on Drying: Not more than 5.0%

•  pH (1% w/v solution): Between 5.5 and 7.5

•  Microbial Limits: Complies with veterinary pharmacopeial microbial standards

•  Heavy Metals: Within permissible limits

•  Homogeneity: Uniform dispersion of actives in each batch

•  Shelf Life: Minimum 24 months under recommended storage conditions

This formulation is indicated for the treatment and prevention of bacterial infections in poultry and livestock, especially:

•  Respiratory tract infections (CRD, infectious coryza, bronchopneumonia)

•  Gastrointestinal infections (colibacillosis, salmonellosis, enteritis)

•  Urinary tract infections

•  Septicaemia

•  Route: Oral, via drinking water or mixed with feed

•  General Dosage:

           o  Poultry: 1 gm per 1–2 litres of drinking water or 1 kg feed for 3–5 days

          o  Livestock (Cattle, Sheep, Goats, Pigs): 15–30 mg/kg body weight per day for 3–5 days

•  Dosage may be adjusted by the veterinarian depending on severity and species

•  Veterinary oral powder

•  Available pack sizes: 100 gm, 250 gm, 500 gm, 1 kg

•  Designed for easy dispersion in feed or drinking water

•  Dual-mode antibacterial action via synergistic folic acid synthesis inhibition

• Bactericidal activity against a wide range of Gram-negative and Gram-positive bacteria

•  Effective against respiratory, enteric, and systemic infections

•  Resistance development is slower due to potentiated mechanism

•  Rapid onset of action with excellent bioavailability

•  Improves overall animal health and productivity

•  Safe and effective when used as directed

•  Occasional gastrointestinal upset such as diarrhoea or reduced feed intake

•  Rare hypersensitivity reactions including skin rash or respiratory signs

•  Overdosage or prolonged use may cause crystalluria or nephrotoxicity

•  Animals should be adequately hydrated during treatment

•  Discontinue use immediately if signs of toxicity appear and consult a veterinarian

•  Meat: Minimum 7 days after last administration

•  Milk: Minimum 3 days withdrawal in lactating animals

•  Eggs: Minimum 7 days if used in laying birds

•  Always follow withdrawal periods to avoid antimicrobial residues in food products

•  Store in a cool, dry, well-ventilated area below 30°C

•  Protect from direct sunlight and moisture

•  Keep the container tightly closed when not in use

•  Wear protective gloves and mask during handling to avoid inhalation or skin contact

•  Keep away from children and unauthorized personnel

•  Dispose of unused material and containers in accordance with local regulations

•  HS Code: 2942.00 — Other antibiotics; sulphonamides

•  HSN Code (India): 2942 — Sulphonamides and their derivatives for pharmaceutical use

•  Use only under veterinary supervision

•  Not for use in animals with known hypersensitivity to sulphonamides or trimethoprim

•  Avoid concurrent use with other nephrotoxic drugs

•  Ensure adequate water intake during therapy

•  Do not mix with acidic drugs or supplements in water/feed

•  Follow complete treatment duration even if symptoms subside early

•  Do not use in animals with renal or hepatic impairment unless advised by a veterinarian

•  Ensure accurate dosage based on body weight or feed/water intake

•  Veterinary Use Only

•  Not for human use or consumption

•  Both Sulphadiazine and Trimethoprim are regulated veterinary antimicrobials

•  Avoid human exposure during handling; wear protective equipment

• In case of accidental ingestion or contact, seek medical attention immediately

•  Strictly observe withdrawal periods to ensure no drug residues in milk, meat, or eggs

Q: What is Sulphadiazine (SDZ)?

A: Sulphadiazine (SDZ) is a sulphonamide antibiotic that inhibits bacterial folic acid synthesis and is effective against various bacterial infections.

Q: What is Trimethoprim (TMP)?

A: Trimethoprim (TMP) is an antibiotic that enhances the activity of sulphonamides by inhibiting dihydrofolate reductase in bacterial cells, leading to synergistic bactericidal action.

Q: What types of infections does this combination treat?

A: It treats respiratory, gastrointestinal, urinary, and systemic infections caused by susceptible bacteria in livestock and poultry.

Q: How is this product administered?

A: It is given orally, either by mixing with feed or dissolving in drinking water, according to veterinary dosage instructions.

Q: Is there a withdrawal period?

A: Yes. Meat: 7 days, Milk: 3 days, Eggs: 7 days. Always adhere to local regulatory guidelines.

Q: Can this product be used in all animal species? A: It is suitable for poultry and major livestock animals but should only be used under veterinary supervision.

Q: What precautions should be taken during use? A: Ensure hydration, avoid overdose, and observe for adverse reactions. Use PPE while handling the powder.

Q: How should the product be stored? A: Store below 30°C in a cool, dry place, protected from sunlight and moisture.