This veterinary bolus combines Ciprofloxacin Hydrochloride I.P. (equivalent to Ciprofloxacin 1500 mg), a second-generation fluoroquinolone antibacterial, with Tinidazole I.P. 1800 mg, a nitroimidazole-class antimicrobial. Designed for oral administration in large animals, this bolus is intended for treatment of mixed infections — particularly those caused by aerobic bacteria, anaerobes, and protozoa — with a focus on gastrointestinal and systemic infections in livestock.

Composition per bolus:

•  Ciprofloxacin Hydrochloride I.P. (eq. to Ciprofloxacin) – 1500 mg

•  Tinidazole I.P. – 1800 mg

•  Excipients – q.s.

Excipients may include: Lactose monohydrate, microcrystalline cellulose, starch, magnesium stearate, disintegrants, and coating agents (if applicable), all conforming to Indian Pharmacopoeia (I.P.) or equivalent veterinary quality standards.

Dosage Form: Solid oral veterinary bolus (intended for ruminants or large animals)

Appearance: Oblong or oval-shaped bolus; white to off-white in colour; embossed or plain depending on branding.

Pharmacological Class:

•  Ciprofloxacin: Fluoroquinolone Antibacterial

•  Tinidazole: Nitroimidazole Antiprotozoal and Anaerobic Antibacterial

Therapeutic Use: Broad-spectrum antimicrobial bolus for oral administration in animals

Indicated in the treatment of:

•  Gastrointestinal infections (diarrhoea, dysentery, enteritis) of mixed bacterial and protozoal origin

•  Calf scours, colibacillosis, salmonellosis, amoebiasis

•  Anaerobic infections in the intestinal tract and other tissues

•  Protozoal infections such as giardiasis, trichomoniasis

•  Post-surgical or secondary infections in livestock

•  Mixed infections in respiratory, urinary, or reproductive tracts (if systemic coverage appropriate)

Route of Administration: Oral — via whole bolus administration

Recommended Dosage:

•  1 bolus once daily for 3 to 5 days, or as directed by the attending veterinarian

•  Adjust according to species, body weight, and clinical condition

Method: Administer using a bolus applicator or manually, ensuring full ingestion. Follow with water or feed as needed.

•  Enhanced antimicrobial synergy with fluoroquinolone + nitroimidazole combination

•  Broad-spectrum action against aerobic, anaerobic, and protozoal pathogens

•  Effective in mixed gastrointestinal infections, especially where bacterial and protozoal coinfection is suspected

•  Oral administration reduces stress and cost versus injectable therapies

•  Short-course, high-dose strategy suitable for acute treatment in livestock

Possible side effects include:

•  Mild gastrointestinal disturbances (vomiting, diarrhoea, loss of appetite)

•  Rare hypersensitivity reactions (rash, swelling, pruritus)

•  Neurological signs in overdose (ataxia, dizziness, head tilt)

•  Potential for cartilage toxicity in young animals (fluoroquinolone class risk)

•  Changes in gut flora balance; risk of secondary infections with prolonged use

•  Do not use in animals known to be allergic to fluoroquinolones or nitroimidazoles

•  Use cautiously in growing animals; avoid in neonates unless necessary

•  Contraindicated in pregnant or lactating animals unless under strict veterinary guidance

•  Avoid concurrent use with drugs that prolong QT interval or known nephrotoxic agents

•  Discontinue immediately if signs of CNS toxicity or allergic reaction appear

Meat: At least 28 days after last administration

Milk: At least 7 days if used in lactating animals

Always verify with local veterinary drug regulatory authorities for official withdrawal periods. Maintain accurate treatment records for compliance.

•  Store in a cool, dry place, below 30°C

•  Protect from light, moisture, and extreme temperatures

•  Keep in original packaging until time of use

•  Do not use after expiry date printed on label

•  Wear gloves when administering

•  Avoid direct contact with broken or crushed bolus

•  Wash hands after handling/ Dispose of unused or expired product according to veterinary waste protocols

•  Schedule H (India) equivalent – Veterinary use only

•  Prescription veterinary drug – Not for retail sale without a registered veterinary prescription

•  Regulated under the Drugs and Cosmetics Act (India) or corresponding legislation in the region of use

•  HS Code (International): 3004.90 – Medicaments for veterinary use

•  HSN Code (India): 30049099 – Other veterinary medicaments (not elsewhere specified)

Veterinary Use Only

•  Formulated specifically for large animal pharmacokinetics

•  Bolus size, excipients, and dosing unsuitable for humans

•  Human use is strictly prohibited

Human Medications Note: Though ciprofloxacin and tinidazole are used in humans, this veterinary bolus is not equivalent to human tablets or suspensions. Misuse poses serious risks

•  Use only under the supervision of a licensed veterinarian

•  Do not split, crush, or dissolve the bolus — administer whole

•  Keep detailed records of administration: date, animal ID, dosage, and withdrawal dates

•  Avoid misuse for growth promotion — this is a therapeutic product only

Q: What does Ciprofloxacin treat in animals?

A: Ciprofloxacin is a fluoroquinolone antibiotic used against a wide range of gram-negative and some gram-positive bacteria, effective in systemic and gastrointestinal infections.

Q: What is Tinidazole's role in this bolus?

A: Tinidazole is an antiprotozoal and ant anaerobic agent, ideal for treating intestinal protozoal infections and anaerobic bacterial infections that co-occur in livestock.

Q: Can this be used in pregnant animals?

A: Use is not recommended unless prescribed by a veterinarian. Risk-benefit must be carefully evaluated.

Q: How should I administer the bolus?

A: Insert carefully using a bolus gun or manually for large ruminants. Ensure full swallowing. Provide water or feed to assist.

Q: Can I use this product in small animals (e.g., dogs, goats)? A: Only if specifically approved by a veterinarian. This dosage form is formulated for large animals and may not be safe or effective in small species.

Q: What happens if I miss a dose? A: Administer the missed dose as soon as possible. Do not double-dose. Maintain a consistent schedule for maximum efficacy.