A broad-spectrum antimicrobial and antiprotozoal veterinary bolus combining Norfloxacin (I.P.) 1200 mg, a fluoroquinolone antibacterial, with Tinidazole (I.P.) 1800 mg, a nitroimidazole-class antiprotozoal and anaerobic antibacterial. Designed for oral administration in large animals, it is indicated for mixed infections involving aerobic bacteria, anaerobes, and protozoa, especially in the gastrointestinal tract.

Composition per bolus:

•  Norfloxacin I.P. – 1200 mg

•  Tinidazole I.P. – 1800 mg

•  Excipients – q.s. (quantum satis/as required)

  Excipients may include: Microcrystalline cellulose, starch, lactose, magnesium stearate, disintegrants, and film coating agents (if applicable). All excipients comply with Indian Pharmacopoeia (I.P.) or equivalent veterinary standards.

Dosage Form: Solid oral bolus — large-size tablet formulated for administration to cattle, buffalo, and other large ruminants.

Colour and Appearance: Off-white to cream-coloured bolus; smooth finish; debossed or unmarked depending on manufacturer branding.

Pharmacotherapeutic Classification:

•  Antibacterial (Fluoroquinolone class)

•  Antiprotozoal and Ant anaerobic (Nitroimidazole class)

Therapeutic Category: Broad-spectrum antimicrobial for veterinary gastrointestinal infections.

Indicated for treatment and control of:

•  Bacterial enteritis and gastroenteritis

•  Mixed infections involving both bacteria and protozoa

•  Calf scours, colibacillosis, salmonellosis

•  Dysentery and amoebiasis in livestock

•  Anaerobic infections of the gastrointestinal tract

•  Trichomoniasis and giardiasis in applicable species

Route: Oral (via direct administration of bolus)

Recommended Dosage:

•  1 bolus daily for 3 to 5 consecutive days depending on severity and veterinary assessment.

•  Adjust based on species, body weight, and clinical condition.

Note: Administer using a bolus gun or manually, ensuring safe and complete swallowing.

•  Dual-spectrum coverage: targets both bacterial and protozoal pathogens

•  Highly effective in mixed gastrointestinal infections

•  Oral route is non-invasive, convenient, and ideal for herd treatment

•  Reduced frequency of treatment failure due to broad pathogen coverage

•  Enhances recovery and reduces animal stress and weight loss during illness

Possible reactions include:

•  Gastrointestinal disturbances: nausea, mild diarrhoea

•  Reduced appetite or feed aversion

•  Hypersensitivity or allergic reactions (rare)

•  Cartilage toxicity in young, growing animals (fluoroquinolone class effect)

•  Neurological signs in overdose (ataxia, incoordination)

Always observe animals after dosing. Stop use and consult a veterinarian if adverse effects occur

•  Do not use in animals with known hypersensitivity to fluoroquinolones or nitroimidazoles

•  Not recommended in pregnant or lactating animals unless advised by a licensed veterinarian

•  Use with caution in growing animals — norfloxacin may impact joint development

•  Avoid concurrent use with drugs that interact with quinolones (e.g. NSAIDs or other antimicrobials)

•  Maintain hydration during diarrhoea treatment

Meat: Minimum of 28 days after last dose Milk: Minimum of 7 days (if applicable in lactating animals)

Note: Follow local veterinary regulations for exact withdrawal periods. Never send animals to slaughter or milk collection before expiry of full withdrawal duration.

•  Store below 30°C in a cool, dry place

•  Protect from direct sunlight and moisture

•  Keep bolus in original strip packaging until use

•  Keep out of reach of children and non-target species

•  Wear gloves while administering

•  Wash hands thoroughly after handling

•  Do not crush or split the bolus

•  Dispose of used packaging and expired product as per environmental guidelines

•  Schedule H equivalent (Veterinary prescription required)

•  Not for retail sale without prescription of a registered veterinarian

•  Regulated under the Drugs and Cosmetics Act (India) / similar authority

•  HS Code (Harmonized System): 3004.90 (Medicaments for veterinary use)

•  HSN Code (India): 30049099 (Other medicaments for veterinary use – not elsewhere classified)

Veterinary Use Only

•  Specifically formulated for use in animals

•  Excipients and dosage forms tailored to livestock pharmacokinetics

•  Human use is prohibited and unsafe due to dosing, formulation, and excipient variation

•  Always administer under veterinary supervision

•  Complete the full course of treatment, even if symptoms improve early

•  Maintain records of dosage, treatment dates, and withdrawal timelines

•  Avoid use as growth promoter or routine prophylaxis — follow rational use guidelines

Q: What is Norfloxacin and what does it treat?

A: Norfloxacin is a fluoroquinolone antibiotic effective against gram-negative bacteria, especially in gastrointestinal infections.

Q: What is Tinidazole used for?

A: Tinidazole is an antiprotozoal and ant anaerobic agent, used to treat infections like giardiasis, trichomoniasis, and amoebiasis.

Q: Can I give this to calves or kids?

A: Caution is advised in young animals due to risk of joint issues. Use only if prescribed by a veterinarian.

Q: Can it be used in dairy animals?

A: Yes, but respect milk withdrawal period strictly (minimum 7 days or as per label).

Q: What if the animal spits out the bolus?

A: Re-administer carefully, possibly using a bolus gun. Ensure full dose is ingested.

Q: Is this bolus safe during pregnancy?

A: Not routinely recommended. Use only under veterinary guidance after assessing benefit vs. risk.

Q: Can this be used with other medications?

 A: Avoid combining with other antibiotics or NSAIDs unless advised. May interact with certain drugs.